Characterizing left ventricular stiffness in women with signs and symptoms of ischemia with no obstructive coronary arteries

Abstract Background Women with signs and symptoms of ischemia no obstructive coronary arteries (INOCA) have evidence diastolic dysfunction are at increased risk developing heart failure preserved ejection fraction (HFpEF). However, mechanisms contributing to HFpEF development poorly understood often attributed underlying cardiovascular factors. Purpose To compare clinical, invasive, imaging parameters in women suspected INOCA various degrees left ventricular (LV) stiffness (as measured by invasive end-diastolic pressure [EDP]/end volume [EDV]). Methods underwent LV pressure-volume loop analysis rest function testing a Doppler wire the anterior descending artery. Intracoronary vasoactive substances (adenosine, acetylcholine, nitroglycerin) were infused into main artery, as published. Rest adenosine stress cardiac magnetic resonance (CMR) was performed evaluate function, structure, perfusion, fibrosis. different tertiles EDP/EDV ratio compared using t-tests. Results A total 62 complete data included; 2 did not CMR. Compared lower tertile, upper tertile older, had higher fraction, mass/volume ratio, worse greater aortic microvascular (Table 1). Traditional factors significantly different. Conclusion Among INOCA, older age, dysfunction, related rest. Those highest hyperdynamic systolic smallest size. More work is needed understand contribution progression. Funding Acknowledgement Type funding sources: Other. Main source(s): National Institutes HealthErika Glazer Women's Heart Health Project